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Item number: TGM-T10270-100mg

Description: BAY 2416964, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist (example 192, IC50: 341 nM), shows potential for cancer treatment. Target: Aryl Hydrocarbon Receptor. Smiles: C[C@@H](CO)NC(=O)c1cc(nn(-c2cnn(C)c2)c1=O)-c1ccc(Cl)cc1. References: Ilona GUTCHER, et al....

CAS	2242464-44-2
MW:	387.82 D

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BAY-2416964

Item number: Cay36939-10

BAY-2416964 is an antagonist of the aryl hydrocarbon receptor (AhR, IC50 = 22 nM in U87 cells). It decreases the mRNA expression of the AhR target genes CYP1A1 and AHRR induced by the AhR agonist kynurenic acid (Cay-16792) in LPS-stimulated isolated human monocytes when used at a concentration of 100 nM. BAY-2416964...

Keywords:	6-(4-chlorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-4-pyridazinecarboxamide
Application:	AhR antagonist
CAS	2242464-44-2
MW:	387.8 D

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