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MT-802
Item number: TGM-T16157-100mg
Description: MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL). Target: PROTACs, BTK. Smiles: NC1=C2C(=NN(C2=NC=N1)C3CCN(CCOCCOCC(NC=4C=C5C(=CC4)C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=O)CC3)C7=CC=C(OC8=CC=CC=C8)C=C7....
| Application: | BTK degradation driving PROTAC |
| CAS | 2231744-29-7 |
| MW: | 787.82 D |
From 147.00€
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MT-802
Item number: Cay36581-25
MT-802 is a proteolysis-targeting chimera (PROTAC) composed of the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (Cay-16274) linked to the cereblon inhibitor pomalidomide (Cay-19877). It induces degradation of BTK in NAMALWA cells when used at concentrations ranging from 10 to 250 nM. MT-802 (1 µM) induces BTK...
| Keywords: | 2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-p... |
| Application: | BTK degradation driving PROTAC |
| CAS | 2231744-29-7 |
| MW: | 787.8 D |
From 58.00€
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