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FLT3-IN-3
Item number: Cay36106-1
FLT3-IN-3 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3). It inhibits wild-type, FLT3D835Y, and FLT3 bearing internal-tandem duplication (FLT3-ITD, IC50s = 13, 8, and 3 nM, respectively). FLT3-IN-3 suppresses the growth of MV4-11 acute myeloid leukemia (AML) cells that express FLT3-ITD (GI50 = 7 nM). It...
| Keywords: | SAN50900, N2-(trans-4-aminocyclohexyl)-9-cyclopentyl-N6-[4-(4-morpholinylmethyl)phenyl]-9H-purine-2,6-diamine |
| Application: | FLT3 inhibitor |
| CAS | 2229050-90-0 |
| MW: | 490.6 D |
From 86.00€
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FLT3-IN-3
Item number: TGM-T11298-100mg
Description: FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively. Target: FLT. Smiles: N[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(CN3CCOCC3)cc2)c2ncn(C3CCCC3)c2n1. References: Gucký T, et al. Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl-...
| CAS | 2229050-90-0 |
| MW: | 490.64 D |
From 107.00€
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