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GSK3368715 hydrochloride
Item number: TGM-T84982-10mg
Description: GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595...
| Keywords: | GSK715 hydrochloride |
| Application: | Type I PRMT inhibitor |
| CAS | 2227587-25-7 |
| MW: | 403 D |
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GSK3368715 (hydrochloride)
Item number: Cay34886-1
GSK3368715 is an inhibitor of type I protein arginine methyltransferases (PRMTs, IC50s = 3.1, 162, 38, 4.7, and 39 nM for PRMT1, 3, 4, 6, and 8, respectively). It is selective for type I PRMTs over PRMT5, 7, and 9 (IC50s = >20,408, >40,000, and >15,000 nM, respectively), as well as 20 additional methyltransferases...
| Keywords: | N1-[[3-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl]methyl]-N1,N2-dimethyl-1,2-ethanediamine, monohydrochloride |
| Application: | Type I PRMT inhibitor |
| CAS | 2227587-25-7 |
| MW: | 403 D |
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