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Item number: Cay37347-1

GSK547 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1, IC50 = 31 nM). It is selective for RIPK1 over a panel of 371 kinases, including RIPK2, -3, -4, and -5, at 10 µM. In vivo, GSK547 (100 mg/kg) increases survival and reduces tumor volume and the number of liver metastases in a P48Cre...

Keywords:	RIP1i, 6-[4-[[(5S)-5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]carbonyl]-1-piperidinyl]-4-pyrimidinecarbonitrile
Application:	RIPK1 inhibitor
CAS	2226735-55-1
MW:	396.4 D

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