Description: Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM. Target: CDK. Smiles: N(NC1=CC=C(S(N)(=O)=O)C=C1)=C2C=3C(NC2=O)=CC=C(Br)C3. References: S T Davis, et al. Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. Science. 2001 Jan 5,291(5501):134-7.

The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM). It is cell permeable, reversible, and ATP-competitive.Formal Name:...