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Item number: Cay36653-10

PK68 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1, IC50 = 90 nM). It is selective for RIPK1 over RIPK3 and a panel of 369 kinases at 1,000 nM. PK68 inhibits necroptosis induced by TNF-alpha, a Smac mimetic, and z-VAD in HT-29 colon cancer cells (EC50 = 23 nM). It reduces the number of...

Keywords:	N-[5-[2-(acetylamino)-6-benzothiazolyl]-2-methyl-3-pyridinyl]-carbamic acid, cyclohexyl ester
Application:	RIPK1 inhibitor
CAS	2173556-69-7
MW:	424.5 D

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