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Item number: TGM-T16761-100mg

Description: RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively). Target: Others, PARP. Smiles: OCCN1CC2(CCN(CC2)c2nc3CCCCc3c(=O)[nH]2)c2c1cc(F)cc2F. References: Mizutani A, et al. RK-287107, a potent and specific tankyrase inhibitor,...

Application:	TNKS1/2 inhibitor
CAS	2171386-10-8
MW:	416.46 D

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RK-287107

Item number: Cay30998-1

RK-287107 is an inhibitor of the tankyrases TNKS1 and TNKS2 (IC50s = 0.014 and 0.010 µM, respectively). It is selective for TNKS1 and TNKS2 over poly(ADP-ribose) polymerase 1 (PARP1), PARP2, and PARP10 (IC50s = >20, 2.7, and 19.8 µM, respectively). RK-287107 inhibits Wnt-dependent signaling with an IC50 value of...

Keywords:	2-[4,6-difluoro-1-(2-hydroxyethyl)spiro[3H-indole-3,4'-piperidine]-1'(2H)-yl]-5,6,7,8-tetrahydro-4(3H)-quinazolinone
Application:	TNKS1/2 inhibitor
CAS	2171386-10-8
MW:	416.5 D

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