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Item number: Cay41731-1

BI-3802 is a degrader of Bcl-6 with a half-maximal degradation concentration (DC50) value of 20 nM in SU-DHL-4 B cell lymphoma cells. It binds to Bcl-6 in a cell-free assay and inhibits the interaction of Bcl-6 with nuclear receptor co-repressor 1 (NCOR1) in a reporter assay (IC50s = =3 and 43 nM, respectively)....

Keywords:	rel-2-[[6-[[5-chloro-2-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,2-dihydro-1-methyl-2-oxo-3-quinolinyl]o...
Application:	Bcl-6 degrader
CAS	2166387-65-9
MW:	485 D

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BI-3802

Item number: TGM-T5408-100mg

Description: BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of =3 nM. It induces polymerization of BCL6 and facilitates its degradation in a manner dependent on the E3 ligase SIAH1, demonstrating notable antitumor activity[1][2]. Target:...

CAS	2166387-65-9
MW:	484.98 D

From 147.00€ *

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