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HS-1371
Item number: TGM-T6815-100mg
Description: HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM. Target: RIP kinase. Smiles: Cc1ccc(Oc2ccnc3cc(ccc23)-c2cnn(c2)C2CCNCC2)cc1. References: Park HH, Park SY, Mah S et al.HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis[J]. Exp Mol...
| Application: | RIPK3 inhibitor |
| CAS | 2158197-70-5 |
| MW: | 384.47 D |
From 48.00€
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HS-1371
Item number: Cay31033-5
HS-1371 is a receptor-interacting serine/threonine kinase 3 (RIPK3) inhibitor (IC50 = 20.8 nM). It inhibits basal RIPK3 autophosphorylation and TNF-alpha- or TRAIL-induced necroptosis in HT-29 cells when used at a concentration of 5 µM. It also inhibits necroptosis induced by a TNF-alpha Smac mimetic and the caspase...
| Keywords: | 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-quinoline |
| Application: | RIPK3 inhibitor |
| CAS | 2158197-70-5 |
| MW: | 384.5 D |
From 133.00€
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