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RWJ-67657
Item number: TGM-T16812-100mg
Description: RWJ-67657 (JNJ 3026582) is an orally active, selective p38alpha and p38beta MAPK inhibitor (IC50s: 1 and 11 µM, respectively), with no activity at p38gamma and p38delta, and demonstrates cardioprotective effects. Target: p38 MAPK. Smiles: OCCC#Cc1nc(c(-c2ccncc2)n1CCCc1ccccc1)-c1ccc(F)cc1. References:...
| Keywords: | JNJ 3026582 |
| Application: | p38 alpha inhibitor, p38 beta inhibitor |
| CAS | 215303-72-3 |
| MW: | 425.5 D |
From 40.00€
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RWJ 67657
Item number: Cay18718-1
RWJ 67657 is an orally active inhibitor of the MAP kinases p38alpha and p38beta (IC50s = 1 and 11 µM, respectively, in vitro) that is inactive against p38gamma and p38delta, as well as several other kinases. It blocks the release of TNF-alpha and IL-1beta from peripheral blood mononuclear cells stimulated with LPS...
| Keywords: | JNJ-3026582, 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol |
| Application: | p38 alpha inhibitor, p38 beta inhibitor |
| CAS | 215303-72-3 |
| MW: | 425.5 D |
From 61.00€
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RWJ-67657
Item number: SYN-1072-M001
Soluble in DMSO or ethanol. The cytokine Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes/macrophages and T lymphocytes and has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage...
| Keywords: | RWJ67657 |
| Application: | p38 inhibitor |
| CAS | 215303-72-3 |
| MW: | 425,5 D |
From 77.00€
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