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SHIN1
Item number: TGM-T12897L-100mg
Description: SHIN1 (RZ-2994) is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM. Target: Others. Smiles: CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1. References: Ducker GS, et al. Human SHMT...
| Keywords: | RZ-2994 |
| Application: | Serine hydroxymethyltransferase SHMT1 / SHMT2 inhibitor |
| CAS | 2146095-85-2 |
| MW: | 400.47 D |
From 71.00€
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SHIN 1
Item number: Cay35715-1
SHIN 1 is an inhibitor of serine hydroxymethyltransferase 1 (SHMT1) and SHMT2 (IC50s = 5 and 13 nM, respectively). It inhibits proliferation of H1299 non-small cell lung cancer (NSCLC) cells overexpressing the proto-oncogene FRAT1 (IC50 = 0.6 µM). SHIN 1 decreases tumor volume in an NSCLC mouse xenograft model using...
| Keywords: | RZ2994,... |
| Application: | Serine hydroxymethyltransferase SHMT1 / SHMT2 inhibitor |
| CAS | 2146095-85-2 |
| MW: | 400.5 D |
From 48.00€
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