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Brepocitinib P-Tosylate
Brepocitinib P-Tosylate

Item number: TGM-T12427-100mg

Description: Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively). Target: JAK. Smiles: Cc1ccc(cc1)S(O)(=O)=O.Cn1cc(Nc2nccc(n2)N2CC3CCC(C2)N3C(=O)[C@@H]2CC2(F)F)cn1. References: Fensome A, et al. Dual Inhibition of TYK2...
Keywords: PF-06700841 P-Tosylate
Application: Targets Janus kinase 1 [EC:2.7.10.2] (JAK1)
CAS 2140301-96-6
MW: 561.6 D
From 31.00€ *
Review
PF-06700841 (tosylate)
PF-06700841 (tosylate)

Item number: Cay26125-5

PF-06700841 is an inhibitor of JAK1 and tyrosine kinase 2 (TYK2, IC50s = 17 and 23 nM, respectively). It is selective for JAK1 and TYK2 over JAK2 and JAK3 (IC50s = 77 and 6,494 nM, respectively). PF-06700841 selectively inhibits IFN-alpha/STAT3 signaling over erythropoietin/STAT5 signaling in human whole blood...
Keywords: [(1S)-2,2-difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-meth...
Application: JAK1 / TYK2 inhibitor
CAS 2140301-96-6
MW: 561.6 D
From 44.00€ *
Review