Description: FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 µM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor...

FX11 is an inhibitor of lactate dehydrogenase-A (LDH-A, Ki = 8 µM). It is selective for LDH-A over GAPDH (Ki = >300 µM). FX11 increases oxygen consumption and the production of reactive oxygen species (ROS), as well as induces cell death in P493-6 lymphoblastoid cells. In vivo, FX11 (42 µg/animal, i.p.) reduces...