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GSK2850163
Item number: TGM-T11488-100mg
Description: GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1alpha), effectively inhibiting both its RNase activity and IRE1alpha kinase activity (IC50s: 200 and 20 nM). Target: IRE1. Smiles: Cc1ccc(CNC(=O)N2CCC[C@]3(CCN(Cc4ccc(Cl)c(Cl)c4)C3)C2)cc1. References: Nestor O. Concha, et al....
| CAS | 2121989-91-9 |
| MW: | 446.41 D |
From 63.00€
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GSK2850163
Item number: Cay40917-10
GSK2850163 is an inhibitor of inositol-requiring enzyme 1alpha (IRE1alpha, IC50s = 0.2 and 0.02 µM for RNase and kinase activity, respectively). It is selective for IRE1alpha over Ron and FGFR1 (IC50s = 4.4 and 17 µM), as well as a panel of 282 kinases at 10 µM. GSK2850163 (8 µM) inhibits endoplasmic reticulum (ER)...
| Keywords: | GSK163, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-2,7-diazaspiro[4.5R]decane-7-carboxamide |
| Application: | IRE1alpha kinase / RNase inhibitor |
| CAS | 2121989-91-9 |
| MW: | 446.4 D |
From 101.00€
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