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Item number: TGM-T16850-100mg

Description: SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively). Target: CXCR. Smiles: Brc1ccccc1NC(=O)Nc1ccc(C#N)c2nn[nH]c12....

Keywords:	GSK-CXCR2
Application:	Allosteric, inverse CXCR2 agonist
CAS	211096-49-0
MW:	357.16 D

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SB 265610

Item number: Cay17879-10

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and many other CXC chemokines involved in the trafficking and activation of inflammatory cells. It is involved in various inflammatory diseases, including chronic obstructive pulmonary disease,...

Keywords:	N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-urea
Application:	Allosteric, inverse CXCR2 agonist
CAS	211096-49-0
MW:	357.2 D

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