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Item number: Cay26150-1

AT-121 is a dual µ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPgammaS binding to cell membranes expressing µ-opioid or nociceptin receptors (EC50s = 19.6 and 34.7 nM, respectively). AT-121 (0.003-0.03 mg/kg) decreases capsaicin-induced thermal...

Keywords:	N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]-sulfamide
Application:	Dual ?-opioid / nociceptin receptor partial agonist
CAS	2099681-31-7
MW:	462.6 D

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