Description: MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively). Target: Ras, CDK. Smiles: CCn1c2ccccc2c2cc(ccc12)-n1nncc1-c1ccccc1. References: Humphries-Bickley T, et al. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic...

MBQ-167 is a dual inhibitor of Rac and cell division cycle 42 (Cdc42, IC50s = 103 and 78 nM, respectively). It reduces Rac and Cdc42 GTP binding and GTPase activity and limits migration and mammosphere formation in MDA-MB-231 breast cancer cells when used at a concentration of 250 nM. MBQ-167 (250 nM), alone and in...