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VH298
Item number: Cay21133-1
VH298 is a cell-permeant inhibitor of von Hippel-Lindau disease tumor suppressor (VHL, Kd = 90 nM by isothermal titration calorimetry). VHL is a component of the complex that polyubiquitinates hydroxylated hypoxia-inducible factor-alpha (HIF-alpha) isoforms leading to proteasomal degradation. Through its effects on...
| Keywords: | (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyr... |
| Application: | Cell-permeant VHL inhibitor |
| CAS | 2097381-85-4 |
| MW: | 523.7 D |
From 50.00€
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VH-298
Item number: BPS-82057
VH-298 is a E3 ligase ligand-linker conjugate that couples the VHL ligand and blocks the interaction between VHL and HIF-alpha, initiating hypoxic response.
| Application: | Protac(R) reagent |
| CAS | 2097381-85-4 |
| MW: | 523,7 D |
1,847.00€
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