Description: APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1. Target: Others. Smiles: S(CC#CCCCC)C1=C(OC(C)=O)C=CC=C1

APHS is an O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and -2, with IC50 values of 17 and 0.8 µM for human recombinant COX-1 and -2, respectively. APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of...