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AOH1996
Item number: TGM-T77520-100mg
Description: AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes...
| Application: | PCNA inhibitor |
| CAS | 2089314-64-5 |
| MW: | 426.46 D |
From 59.00€
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AOH1996
Item number: AG-CR1-3553-M005
AOH1996 is an orally available and metabolically stable small molecule PCNA inhibitor, which selectively kills cancer cells, with a median concentration of about 300 nM for 50% growth inhibition. AOH1996 was not significantly toxic to non-malignant cells, even up to 10 µM. AOH1996 enhances the interaction between...
| Keywords: | NSC789796, N-(2-((2-(3-Methoxyphenoxy)phenyl)amino)-2-oxoethyl)-1-naphthamide |
| CAS | 2089314-64-5 |
| MW: | 426.5 D |
From 132.00€
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AOH1996
Item number: Cay39526-1
AOH1996 is an inhibitor of proliferating cell nuclear antigen (PCNA). It binds to PCNA in a thermal shift assay. AOH1996 (500 nM) induces apoptosis in SK-N-DZ neuroblastoma cells but not 7SMOO32 normal neural crest stem cells. It induces DNA damage in SK-N-AS neuroblastoma cells expressing wild-type DNA-directed RNA...
| Keywords: | N-[2-[[2-(3-methoxyphenoxy)phenyl]amino]-2-oxoethyl]-1-naphthalenecarboxamide |
| Application: | PCNA inhibitor |
| CAS | 2089314-64-5 |
| MW: | 426.5 D |
From 34.00€
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