Description: Suc-YVAD-pNA, a chromogenic caspase-1 substrate. Target: Others. Smiles: CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)N(=O)=O , @@:1,

Suc-YVAD-pNA is a colorimetric substrate for caspase-1/interleukin-1beta-converting enzyme (ICE) and caspase-4. Caspase-1 and caspase-4 preferentially bind to and cleave the Tyr-Val-Ala-Asp (YVAD) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a...