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A1874
Item number: TGM-T5442-100mg
Description: A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation. Target: Epigenetic Reader Domain, PROTACs. Smiles: C(#N)[C@]1([C@H]([C@H](C(NC2=C(OC)C=C(C(NCCOCCOCCO...
| Application: | BRD4 degradation driving PROTAC |
| CAS | 2064292-12-0 |
| MW: | 1173.59 D |
From 223.00€
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A1874
Item number: Cay40842-1
A1874 is a proteolysis-targeting chimera (PROTAC) that contains (+)-JQ1 (Cay-11187), an inhibitor of bromodomain and extra terminal domain (BET) bromodomains, conjugated to RG7388 (Cay-21532), an inhibitor of the MDM2-p53 interaction. It induces the degradation of bromodomain-containing protein 4 (BRD4), decreases...
| Keywords: | (6S)-N-[1-[4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyr... |
| Application: | BRD4 degradation driving PROTAC |
| CAS | 2064292-12-0 |
| MW: | 1173.6 D |
From 72.00€
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