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H3B-5942
Item number: TGM-T5633-100mg
Description: H3B-5942 belongs to a class of ERalpha antagonists referred to as selective estrogen receptor covalent antagonists (SERCA). Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor. Smiles: CC\C(=C(\c1ccc(OCCNC\C=C\C(=O)N(C)C)cc1)c1ccc2[nH]ncc2c1)c1ccccc1. References: Discovery of Selective...
| Application: | Selective estrogen receptor covalent antagonist (SERCA) |
| CAS | 2052128-15-9 |
| MW: | 494.63 D |
From 77.00€
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H3B-5942
Item number: Cay31454-1
H3B-5942 is a selective estrogen receptor covalent antagonist (SERCA). It covalently modifies cysteine 530 in the ligand binding domain of wild-type estrogen receptor alpha (ERalpha) and ERalphaY537S. HB-5942 inhibits expression of the ERalpha target genes GREB1 and TFF1 in MCF-7 cells overexpressing wild-type...
| Keywords: | (2E)-4-[[2-[4-[(1E)-1-(1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]amino]-N,N-dimethyl-2-butenamide |
| Application: | Selective estrogen receptor covalent antagonist (SERCA) |
| CAS | 2052128-15-9 |
| MW: | 494.6 D |
From 60.00€
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