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Item number: TGM-T15767-10mg

Description: LLY-283 is a potent, selective, and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, exhibiting an IC50 of 22 nM and a Kd of 6 nM for the PRMT5:MEP50 complex, and demonstrates antitumor activity. Target: Histone Methyltransferase. Smiles:...

Application:	PRMT5 inhibitor
CAS	2040291-27-6
MW:	342.35 D

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LLY-283

Item number: Cay21596-1

LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5, IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 µM. It reduces symmetric demethylation of SmBB' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric,...

Keywords:	7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Application:	PRMT5 inhibitor
CAS	2040291-27-6
MW:	342.4 D

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