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Porcn-IN-1
Item number: TGM-T4438-100mg
Description: Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM). Target: Porcupine. Smiles: Cc1cc(ccn1)-c1ncc(CNC(=O)c2ccc3c(c2)[nH]c2ccccc32)cc1F. References: Xu Z, Xu X, O'Laoi R, et al. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system...
| Keywords: | Porcupine-IN-1 |
| Application: | Protein-serine O-palmitoleoyltransferase porcupine (PORCN ) inhibitor |
| CAS | 2036044-77-4 |
| MW: | 410.44 D |
From 48.00€
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Porcupine-IN-1
Item number: Cay25834-1
Porcupine-IN-1 is an inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM, respectively, in cell-based reporter assays). It inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells when used at a concentration of 0.1 µM, indicating inhibition of porcupine, an enzyme that catalyzes...
| Keywords: | PORCN-IN-1, N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-9H-carbazole-2-carboxamide |
| Application: | Protein-serine O-palmitoleoyltransferase porcupine (PORCN ) inhibitor |
| CAS | 2036044-77-4 |
| MW: | 410.4 D |
From 97.00€
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