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(R)-GNE-140
Item number: TGM-T4295-100mg
Description: (R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer. Target: Dehydrogenase. Smiles: OC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1. References: Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate...
| Keywords: | GNE-140 |
| Application: | LDHA/LDHB inhibitor |
| CAS | 2003234-63-5 |
| MW: | 499.04 D |
From 67.00€
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GNE-140
Item number: Cay39015-10
GNE-140 is an inhibitor of lactate dehydrogenase A (LDHA) and LDHB (IC50s = 3 and 5 nM, respectively). It reduces lactate production in MiaPaCa-2 pancreatic cancer cells (IC50 = 670 nM). GNE-140 decreases proliferation in a panel of 37 cancer cell lines when used at a concentration of 5 µM.Formal Name:...
| Keywords: | 3-[(2-chlorophenyl)thio]-5,6R-dihydro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-2(1H)-pyridinone |
| Application: | LDHA/LDHB inhibitor |
| CAS | 2003234-63-5 |
| MW: | 499 D |
From 130.00€
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