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APS-2-79 hydrochloride
APS-2-79 hydrochloride

Item number: TGM-T6760-100mg

Description: APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK. Target: MEK, MAPK. Smiles:...
Keywords: APS-2-79, APS-2-79 HCl
Application: KSR-dependent MAPK signaling modulator
CAS 2002381-31-7
MW: 423.89 D
From 38.00€ *
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APS-2-79 (hydrochloride)
APS-2-79 (hydrochloride)

Item number: Cay22137-5

APS-2-79 is an inhibitor of MAPK signaling dependent on kinase suppressor of Ras (KSR). It inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 = 120 nM), stabilizes KSR2 in an inactive state, and reduces interactions between B-RAF and KSR2-MEK1 complexes. APS-2-79 (5 µM) inhibits KSR-stimulated...
Keywords: 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)-4-quinazolinamine, monohydrochloride
Application: KSR-dependent MAPK signaling modulator
CAS 2002381-31-7
MW: 423.9 D
From 45.00€ *
Review