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Item number: TGM-T9568-100mg

Description: SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3), and PB1(5) with Kds of 35 nM, 36 nM, 3.7 µM, 2.0 µM, and 13 nM, respectively. Target: Epigenetic Reader Domain. Smiles: CC(C)(C)OC(=O)N1CCN(CC1)c1cc(nnc1N)-c1ccccc1O. References: Wanior M, et, al. Pan-SMARCA/PB1...

Application:	Pan-family VIII BRD inhibitor
CAS	1997319-84-2
MW:	371.43 D

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SGC-SMARCA-BRDVIII

Item number: Cay33567-1

SGC-SMARCA-BRDVIII is a pan-inhibitor of family VIII bromodomain-containing proteins (BRDs), which are components of switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complexes. It selectively binds to polybromo-1D (PBRM1) bromodomain 5, BRM, also known as SMARCA2, and BRG1, also known as SMARCA4 (Kds =...

Keywords:	4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester
Application:	Pan-family VIII BRD inhibitor
CAS	1997319-84-2
MW:	371.4 D

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