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Item number: TGM-T2764-100mg

Description: (S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor used as a clinical therapeutic agent against hepatoma. Target: Apoptosis, Topoisomerase. Smiles: O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@@]5(CC)O. References: Ling YH, et al. Cancer Biochem Biophys, 1990, 11(1), 23-30.

Keywords:	10-Hydroxycamptothecin, 10-HCPT
Application:	Topoisomerase I inhibitor
CAS	19685-09-7
MW:	364.35 D

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(S)-10-hydroxy-Camptothecin

Item number: Cay14635-25

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of...

Keywords:	ChEMBL 273862, NSC 107124, (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Application:	Topoisomerase I inhibitor
CAS	19685-09-7
MW:	364.4 D

From 78.00€ *

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