3 products were found matching "1951483-29-6"!
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Temuterkib
Item number: TGM-T4091-100mg
Description: Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Target: ERK. Smiles: Cn1nccc1Nc1nccc(n1)-c1cc2C(=O)N(CCN3CCOCC3)C(C)(C)c2s1. References: Shripad V. Bhagwat, et al. Abstract...
| Keywords: | LY3214996 |
| Application: | Targets mitogen-activated protein kinase 1/3 [EC:2.7.11.24] (ERK, MAPK1_3) |
| CAS | 1951483-29-6 |
| MW: | 453.56 D |
From 63.00€
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LY3214996
Item number: Cay27936-1
LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer...
| Keywords: | 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]... |
| Application: | ERK1 / ERK2 inhibitor |
| CAS | 1951483-29-6 |
| MW: | 453.6 D |
From 54.00€
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LY-3214996
Item number: LKT-L960012.100
LY-3214996 is a selective inhibitor of ERK1/2. ERK1/2 inhibitors offer a targeted approach to cancers in which the RAS/MAPK signaling pathway is dysregulated. These compounds can be successful when Braf and MEK inhibitor efficacy is lost due to developed drug resistance. LY-3214996 has demonstrated potent antitumor...
| Keywords: | LY 3214996, LY3214996, LY-3214996 |
| Application: | Selective ERK1/2 inhibitor |
| CAS | 1951483-29-6 |
| MW: | 453.57 D |
From 189.00€
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