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Item number: TGM-T15201-100mg

Description: MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay). Target: Histone Methyltransferase. Smiles: Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12. References: Chan, Ho Man, et al. TRIAZOLOPYRIMID INECOMPOUNDS AND USES THEREOF....

Application:	PRC2 (polycomb repressive complex 2)-mediated H3K27 trimethylation inhibitor
CAS	1951408-58-4
MW:	376.39 D

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MAK-683

Item number: Cay29316-1

MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401...

Keywords:	N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
Application:	PRC2 (polycomb repressive complex 2)-mediated H3K27 trimethylation inhibitor
CAS	1951408-58-4
MW:	376.4 D

From 109.00€ *

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