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PQR620
Item number: Cay26656-1
PQR620 is an inhibitor of mTOR (Ki = 10.8 nM). It is selective for mTOR over PI3K p110alpha (Ki = 4.2 µM) and a panel of 456 other kinases at 10 µM. PQR620 has antiproliferative activity against a panel of 66 cancer cell lines (mean IC50 = 919 nM). It induces cell cycle arrest at the G1 phase in A2058 melanoma and...
| Keywords: | 5-[4,6-bis(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]-4-(difluoromethyl)-2-pyridinamine |
| Application: | mTOR inhibitor |
| CAS | 1927857-56-4 |
| MW: | 445.5 D |
From 48.00€
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PQR620
Item number: TGM-T5472-100mg
Description: PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2. Target: mTOR. Smiles: [H][C@]12CC[C@]([H])(COC1)N2c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1[C@@]2([H])CC[C@]1([H])COC2. References: Florent Beaufils, et al. Abstract 1336: Structure-activity relationship studies, synthesis, and...
| CAS | 1927857-56-4 |
| MW: | 445.47 D |
From 95.00€
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