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DS-1001b
Item number: TGM-T7741-100mg
Description: DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1). Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH). Smiles: CC(C)(C)N.Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12. References: Yoshiki A , Yohei M , Toshihiko W , et al. ACT-14 A FIRST-IN-HUMAN STUDY OF...
| Application: | Mutant IDH1 inhibitor |
| CAS | 1898207-64-1 |
| MW: | 608.92 D |
From 31.00€
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DS-1001b
Item number: Cay31488-1
DS-1001b is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1, IC50s = 15 and 130 nM for IDH1R132H and IDH1R132C, respectively). It is selective for mutant IDH1, which converts alpha-ketoglutarate to the oncometabolite 2-hydroxyglutarate (2-HG), over wild-type IDH1 and IDH2, which convert isocitrate to...
| Keywords: | (2E)-3-[1-[[5-(1-fluoro-1-methylethyl)-3-(2,4,6-trichlorophenyl)-4-isoxazolyl]carbonyl]-3-methyl-1H-indol-4-yl]-2-propenoi... |
| Application: | Mutant IDH1 inhibitor |
| CAS | 1898207-64-1 |
| MW: | 608.9 D |
From 78.00€
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