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Item number: TGM-T5440-100mg

Description: dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2. Target: PROTACs, Epigenetic Reader Domain. Smiles:...

Application:	PROTAC, BRD4BD1 degradation
CAS	1883863-52-2
MW:	699.18 D

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dBET57

Item number: Cay36626-1

dBET57 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ1, which binds bromo- and extra-terminal domain (BET) proteins, linked to thalidomide, a ligand for the E3 ubiquitin...

Keywords:	(6S)-4-(4-chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trime...
Application:	PROTAC, BRD4BD1 degradation
CAS	1883863-52-2
MW:	699.2 D

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