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Item number: Cay28426-1

CXCR2-IN-1 is a chemokine (C-X-C motif) receptor 2 (CXCR2) antagonist (IC50 = 0.501 nM in a reporter assay). It inhibits chemotaxis of isolated human neutrophils induced by chemokine (C-X-C motif) ligand 1 (CXCL1, IC50 = 79.4 nM). In vivo, CXCR2-IN-1 (100 mg/kg) inhibits forebrain lesion formation in a mouse model...

Keywords:	CXCR2 Inhibitor 1, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-urea
Application:	CXCR2 antagonist
CAS	1873376-49-8
MW:	476.3 D

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