Description: Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 µM, 20 µM, and 86 µM for E-selectin, L-selectin, and P-selectin respectively. Target: Integrin. Smiles:...

Bimosiamose is a pan-selectin inhibitor (IC50s = 88, 20, and 86 µM for E-, P-, and L-selectin, respectively). It reduces adhesion of HL-60 cells to E- and P-selectin when used at a concentration of 129 µM. In vivo, bimosiamose (200 mg/kg) reduces skin scaliness, induration, and erythema in a patient-derived...