3PO is a competitive inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 3 (PFKFB3, IC50 = 23 µM) that causes a rapid reduction in fructose-2,6-bisphosphate (F2,6BP), glucose uptake, and lactate secretion. This is followed by a reduction in the steady-state concentration of ATP and NADH, resulting in...

Description: 3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 µM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 µM). It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH....