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Item number: TGM-T7194-100mg

Description: CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor. Target: DNA Methyltransferase, Apoptosis, Histone Methyltransferase. Smiles: COc1cc2c(NC3CCN(C)CC3)cc(nc2cc1OCCCN1CCCC1)-c1ccc(C)o1. References: San José-Enériz, Edurne, Agirre X , Rabal O , et al. Discovery of first-in-class reversible...

Application:	EHMT2/EHMT1/DNMT1/DNMT3A/DNMT3B inhibitor
CAS	1846570-31-7
MW:	478.63 D

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CM-272

Item number: Cay25948-5

CM-272 is a reversible inhibitor of the histone methyltransferases G9a and GLP, as well as DNA methyltransferase 1 (DNMT1), DNMT3A, and DNMT3B (IC50s = 8, 2, 382, 85, and 1,200 nM, respectively). It inhibits the growth of, and induces apoptosis in, CEMO-1, MV4-11, and OCI-LY10 cancer cells (GI50s = 218, 269, and 455...

Keywords:	6-methoxy-2-(5-methyl-2-furanyl)-N-(1-methyl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinolinamine
Application:	EHMT2/EHMT1/DNMT1/DNMT3A/DNMT3B inhibitor
CAS	1846570-31-7
MW:	478.6 D

From 111.00€ *

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