Description: AZD2716 is an effective selective phospholipase A2 inhibitor for the treatment of coronary artery and cardiovascular disease. Target: Others. Smiles: C(N)(=O)C1=C(C=C(CC2=CC=CC=C2)C=C1)C3=CC(C[C@H](C(O)=O)C)=CC=C3. References: An Enantioselective Hydrogenation of an Alkenoic Acid as a Key Step in the...

AZD 2716 is an inhibitor of secretory phospholipase A2 (sPLA2, IC50s = 0.01, 0.04, and 0.4 µM for sPLA2-IIa, -V, and -X, respectively). It inhibits sPLA2 activity in atherosclerotic plaque homogenates isolated from patients with coronary artery disease (IC50 = 56 nM).Formal Name:...