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Item number: TGM-T14120-2mg

Description: ACT-709478 is a potent, selective T-type calcium channel blocker that is orally active and capable of penetrating the brain. It is currently utilized in research focusing on generalized epilepsies[1]. Target: Others. Smiles: FC(F)(F)C1(CC1)c1ccc(CC(=O)Nc2ccn(Cc3ccc(cn3)C#N)n2)cc1. References: Bezençon...

Application:	Targets voltage-dependent calcium channel T type alpha-1G (CACNA1G, CAV3.1)
CAS	1838651-58-3
MW:	425.41 D

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ACT-709478

Item number: Cay25371-1

ACT-709478 is an inhibitor of T-type voltage-gated calcium channel 3.1 (Cav3.1), Cav3.2, and Cav3.3 (IC50s = 6.4, 18, and 7.5 nM, respectively). It is selective for T-type calcium channels over the L-type calcium channel Cav1.2 (IC50 = 2,410 nM). ACT-701478 (10 mg/kg) reduces the cumulative duration of absence-like...

Keywords:	N-[1-[(5-cyano-2-pyridinyl)methyl]-1H-pyrazol-3-yl]-4-[1-(trifluoromethyl)cyclopropyl]-benzeneacetamide
Application:	T-type calcium channels inhibitor
CAS	1838651-58-3
MW:	425.4 D

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