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L-778123 free base
Item number: TGM-T3182L-10mg
Description: L-778123 is an inhibitor of FPTase and GGPTase-I. The combination of L-778123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Target: Others. Smiles: Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O. References: Ghasemi S, Davaran S, Sharifi...
| Keywords: | L-778123, L778123, L 778,123, L-778,123, L 778123 |
| Application: | Dual FTase / GGTase I inhibitor |
| CAS | 183499-57-2 |
| MW: | 405.88 D |
From 193.00€
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L-778,123
Item number: Cay32504-10
L-778,123 is a dual inhibitor of farnesyl transferase (FTase, IC50 = 2 nM) and geranylgeranyl transferase type I (GGTase I, IC50 = 98 nM). It inhibits prenylation of the FTase and GGTase I substrates HDJ2 and Rap1a in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively). L-778,123 (1-300 µM) also...
| Keywords: | 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-benzonitrile |
| Application: | Dual FTase / GGTase I inhibitor |
| CAS | 183499-57-2 |
| MW: | 405.9 D |
From 109.00€
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