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Item number: Cay10483-250

Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR...

Keywords:	NSC 718781, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
Application:	Tyrosine kinase inhibitor
CAS	183321-74-6
MW:	393.4 D

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Erlotinib

Item number: TGM-T0373-100mg

Description: Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer. Target: Autophagy, EGFR. Smiles: N(C=1C2=C(C=C(OCCOC)C(OCCOC)=C2)N=CN1)C3=CC(C#C)=CC=C3. References: Chin TM, et al. Reduced Erlotinib sensitivity of epidermal growth factor...

Keywords:	R1415, CP358774, OSI-744, NSC 718781
CAS	183321-74-6
MW:	393.44 D

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