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Item number: TGM-T16757-100mg

Description: Risdiplam (RO7034067) (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor neuron (SMN) protein levels[1]. Target: DNA/RNA Synthesis. Smiles: Cc1cn2nc(cc(C)c2n1)-c1cc(=O)n2cc(ccc2n1)N1CCNC2(CC2)C1....

Keywords:	RO7034067, RG7916
Application:	Targets survival motor neuron protein (SMN)
CAS	1825352-65-5
MW:	401.46 D

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Risdiplam

Item number: Cay29028-5

Risdiplam is a survival of motor neuron-2 (SMN2) splicing modifier. It enhances SMN2 splicing (EC1.5x = 40 nM) and increases SMN protein levels (EC1.5x = 163 nM) in cellular assays. Risdiplam (3 mg/kg) increases brain and quadricep muscle SMN protein levels in the adult C/C-allele mouse model of mild spinal muscular...

Keywords:	RG-7916, RO7034067,...
Application:	SMN2 splicing modifier
CAS	1825352-65-5
MW:	401.5 D

From 52.00€ *

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