Description: SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2. Target: CXCR. Smiles: N(C(NC1=C(Br)C=CC=C1)=O)C2=C(O)C=C(N(=O)=O)C=C2. References: White JR, et al. J Biol Chem. 1998, 273(17), 120095-120098.

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene alpha (Gro-alpha, CXCL1). IL-8 and Gro-alpha are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB...