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Zimlovisertib
Item number: TGM-TQ0167-100mg
Description: Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay). Target: IRAK. Smiles: O(C[C@@H]1[C@H](CC)[C@H](F)C(=O)N1)C=2C3=C(C=C(C(N)=O)C(OC)=C3)C=CN2. References: Lee KL, et...
| Keywords: | PF06650833, PF-06650833 |
| Application: | Targets interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1] (IRAK4) |
| CAS | 1817626-54-2 |
| MW: | 361.37 D |
From 41.00€
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PF-06650833
Item number: Cay28397-5
PF-06650833 is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 0.2 nM). It is selective for IRAK4 over a panel of 268 kinases at 200 nM but also inhibits IRAK1, MAP kinase-interacting serine/threonine protein kinase 2 (MNK2), leucine-rich repeat kinase 2 (LRRK2), CDC-like kinase 4 (Clk4), and casein...
| Keywords: | IRAK4i, 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide |
| Application: | IRAK4 inhibitor |
| CAS | 1817626-54-2 |
| MW: | 361.4 D |
From 103.00€
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