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Item number: TGM-TQ0042-10mg

Description: BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1). Target: Isocitrate Dehydrogenase (IDH), Dehydrogenase. Smiles: C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)ccc12. References: Chaturvedi A, et al. Pan-mutant-IDH1...

Application:	Mutant IDH1 inhibitor
CAS	1803274-65-8
MW:	489.53 D

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BAY-1436032

Item number: Cay35709-1

BAY-1436032 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1, IC50 = 0.015 µM for both IDH1R132H and IDH1R132C). It is selective for mutant IDH1 over wild-type IDH1 and IDH2 (IC50s = 20 and >100 µM, respectively). BAY-1436032 inhibits production of alpha-hydroxyglutaric acid (2-HG, Cay-25894, Cay-16374) in...

Keywords:	2-[[4-(trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-propanoic acid
Application:	Mutant IDH1 inhibitor
CAS	1803274-65-8
MW:	489.5 D

From 35.00€ *

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