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Item number: TGM-TQ0040-100mg

Description: ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA alpha5. Target: GABA Receptor. Smiles: Cc1c(F)c(Nc2ccc(cn2)-c2cn(C)cn2)cc2n(CC3CC3)cnc12. References: Kawaharada S, et al. ONO-8590580, a Novel GABAAalpha5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves...

Keywords:	CS-2894
Application:	Alpha5 subunit-containing GABAA receptor (benzodiazepine binding site) negative allosteric modulator
CAS	1802661-73-9
MW:	376.43 D

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ONO-8590580

Item number: Cay35297-10

ONO-8590580 is a negative allosteric modulator of alpha5 subunit-containing GABAA receptors that binds at the benzodiazepine binding site. It binds to alpha1, alpha2, alpha3, and alpha5 subunit-containing GABAA receptors (Kis = 140, 32, 24, and 7.9 nM, respectively). It is selective for inhibiting GABA-induced...

Keywords:	1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-1H-benzimidazol-6-amine
Application:	Alpha5 subunit-containing GABAA receptor (benzodiazepine binding site) negative allosteric modulator
CAS	1802661-73-9
MW:	376.4 D

From 121.00€ *

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