Description: KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1alpha. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a...

KL1333 is a substrate for NAD(P)H:quinone acceptor oxioreductase 1 (NQO1) and a derivative of the quinone beta-lapachone (Cay-15021). It is converted by NQO1 to NAD+ and increases the ratio of NAD+ to NADH in a cell-free assay, as well as C2C12 and L6 myoblasts, when used at concentrations of 1, 1, or 2 µM,...