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Borussertib
Item number: TGM-T8427-100mg
Description: Borussertib is a first-in-class covalent-allosteric inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. Target: Akt. Smiles: C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(Cc4ccc(cc4)-c4nc5cc[nH]c(=O)c5cc4-c4ccccc4)CC3)c2c1. References: Niklas Uhlenbrock, et al. Structural and...
| Application: | Akt1 / Akt2 inhibitor |
| CAS | 1800070-77-2 |
| MW: | 596.68 D |
From 132.00€
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Borussertib
Item number: Cay33387-1
Borussertib is a covalent and allosteric Akt1 and Akt2 inhibitor (Kis = 2 and 6 nM, respectively). It is selective for Akt1 and Akt2 over Akt3 (Ki = 91 nM). Borussertib (5 µM) reduces viability in Ba/F3 cells expressing human Akt1 or Akt2 but not Ba/F3 cells expressing human Akt3. It decreases the levels of...
| Keywords: | N-[3-[1-[[4-(5,6-dihydro-5-oxo-3-phenyl-1,6-naphthyridin-2-yl)phenyl]methyl]-4-piperidinyl]-2,3-dihydro-2-oxo-1H-benzimida... |
| Application: | Akt1 / Akt2 inhibitor |
| CAS | 1800070-77-2 |
| MW: | 596.7 D |
From 98.00€
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